Connection between eye infarction and gut flora established
The research group led by Martin Zinkernagel and Denise Zysset at the Department of Ophthalmology at Bern University Hospital and the Department of Clinical Research, Bern University, has demonstrated specific changes in the composition and function of the gut flora in patients with an eye infarction. An imbalance in the gut flora correlates with the occlusion of the ocular artery. Recommendations for the prevention of eye infarctions can be derived from this.
Eye infarctions occur suddenly – mostly in connection with cardiovascular diseases. An eye infarction occurs in more than twice as many diabetic patients compared to people without a diagnosis of diabetes. The search for correlations between this disease and nutrition and for possible preventive measures is ongoing.
Prof. Dr. Dr. med. Martin Zinkernagel’s research team in Bern has now dedicated for the first time a study to the question of a possible connection between eye infarction and gut flora. It is known from already existing investigations that imbalances of the gut flora have an important effect in impaired fat metabolism and thus in atherosclerosis (popularly known as arteriosclerosis).
Eye infarction – more frequent than previously known
A retinal artery occlusion (RAO) occurs suddenly and can reduce the eye’s vision or even lead to blindness in the affected eye. Minor events often go unnoticed because the remaining, functioning eye can compensate for the visual function. What exactly happens in an eye infarction? Following the same basic pattern as a stroke or a heart attack, an infarction can also occur in the eye. As a rule, the actual event is preceded by a long-lasting vascular disease (atherosclerosis) in which certain blood lipids form deposits on the inner walls of important arterial blood vessels. Blood vessels constricted in this way can suddenly be blocked by a blood clot. Oxygen is withdrawn from the eye; the retina can no longer perform its function and the vision is lost. With immediate specialist intervention, partial or extensive restoration of the eye is possible. If, on the other hand, there is a long delay an eye infarction can cause permanent damage.
Risk factors: environment, genes and nutrition influence the gut flora
The risk factors for cardiovascular diseases have been well investigated and can be roughly divided into three groups: environmental factors, genetic predisposition and behaviour/nutrition. Frequently cited keywords are in this context environmental pollution and stress, smoking and alcohol as well as lack of exercise and poor nutrition. It is known that these factors are associated with a change in the composition of the gut flora. The latter was of particular interest to the research group. The gut flora – the entirety of the microorganisms that colonise the human intestine – plays a decisive role in digestion and influences the metabolism and the immune system. In a healthy adult, this ecosystem consists mainly of bacteria of which totally up to a hundred trillion colonise the intestine. Their composition varies greatly from person to person. However, imbalances in the gut flora – known as dysbiosis or dysbacteria – can impair the metabolism and contribute to the development of metabolic diseases such as atherosclerosis.
Composition of the gut flora researched via gene analysis
The Bernese research team examined the gut flora (intestinal metagenome) of patients who had suffered an eye infarction and of a healthy control group as well. The intestinal metagenome, the totality of the genomic information of the microorganisms in the intestine, was determined by sequencing. The sequencing allows a precise determination of the amount and type of the gut flora components and replaces earlier, very complex and inaccurate examination methods. The study found differences in both the composition and the function of the gut flora. The class Actinobacteria and the species Bifidobacterium adolescentis, Bifidobacterium bifidum, Bacteroides stercoris and Faecalibacterium prausnitzii were increasingly found in the intestines of persons who had suffered an eye infarction. Genetic material of Actinobacteria was found in deposits on the inner walls of the blood vessels. Furthermore, a reduction of the bacterial strain Bacteriodetes in favour of Proteobacteria in patients indicates a dysbiosis and thus a possible atherosclerotic disease.
Amin oxide TMAO: messenger or perpetrator?
Previous studies have shown a link between the production of trimethylamine N-oxide (TMAO) in the intestine and cardiovascular diseases. TMAO is also considered a risk and prognosis marker for atherosclerotic diseases. The Bernese study now found a significant difference in TMAO concentration between patients and persons in the control group. At higher concentrations of TMAO the genus Akkermansia appeared more frequently. The genus Parasuterella and the family Lachnospiraceae showed the opposite behaviour.
Whether an increased TMAO concentration is the cause for the development of atherosclerosis or whether this is only a marker for the differences in the gut flora cannot yet be conclusively proven.
Cardiovascular diseases are closely related to the fat metabolism in the blood. It is known that low-density lipoproteins (LDL) contribute to deposits on the inner walls of the blood vessels. In this context, the isoprene signalling pathway, which provides starting materials for the production of cholesterol, was investigated. It was established that patients who had suffered an eye infarction exhibited increased isoprene biosynthesis.
Consequences and prevention
The data obtained indicate possible ways as to how an eye infarction can be prevented with certain probiotics, antibiotics and an appropriate diet and lifestyle. All results suggest that eye infarction is due to the same causes as stroke and heart attack. It is a metabolic cardiovascular disease. This can be of genetic origin or can be controlled by environmental influences and eating, exercise and addictive behaviour. The general indications of sufficient exercise and avoidance of smoking and alcohol as well as a balanced diet can also be recommended as a measure to prevent eye infarction.
– Prof. Dr. Dr. med. Martin Zinkernagel, Universitätsklinik für Augenheilkunde, Inselspital, Universitätsspital Bern
– Dr. phil. Denise Zysset Burri, Universitätsklinik für Augenheilkunde, Inselspital, Universitätsspital Bern
– Insel Gruppe AG, Kommunikation: +41 31 632 79 25, firstname.lastname@example.org
– Denise C . Zysset-Burri, Irene Keller, Lieselotte E. Berger, Peter J. Neyer, Christian Steuer, Sebastian Wolf & Martin S. Zinkernagel 2019: Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. https://doi.org/10.1038/s41598-019-51698-5
The Insel Gruppe is Switzerland’s leading group of hospitals for university and integrated medicine. It offers comprehensive health care based on ground-breaking quality, research, innovation and education. The six Insel Gruppe hospitals (Inselspital, Aarberg, Belp, Münsingen, Riggisberg and Tiefenau) carried out around 822,000 out-patient consultations and treated over 65,000 in-patients in the financial year 2018.
The Insel Gruppe employs almost 11,000 members of staff from 100 nations. It provides training for a large number of professions and is the most important institution for the further training of young physicians.
Contact for scientific information:
Prof. Dr. Dr. med. Martin Zinkernagel, Universitätsklinik für Augenheilkunde, Inselspital, Universitätsspital Bern
Dr. phil. Denise Zysset Burri, Universitätsklinik für Augenheilkunde, Inselspital, Universitätsspital Bern
Denise C . Zysset-Burri, Irene Keller, Lieselotte E. Berger, Peter J. Neyer, Christian Steuer, Sebastian Wolf & Martin S. Zinkernagel 2019: Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. https://doi.org/10.1038/s41598-019-51698-5