23. Januar 2019, 11:15
Research results, Scientific Publications

Evolution of signaling molecules opens door to new sepsis therapy approaches

Evolution of signaling molecules opens door to new sepsis therapy approaches


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First author Stephanie Müller and Prof. Feige in the Laboratory for Cellular Protein Biochemistry. Image: A. Battenberg / TUM
Evolution of signaling molecules opens door to new sepsis therapy approaches


In regard to the use of pictorial material: use of such material in this press release is remuneration-free, provided the source is named. The material may be used only in connection with the contents of this press release. For pictures of higher resolution or inquiries for any further use, please contact the Press office publishing this directly.
Modified human interleukin-27-alpha. Inspired by the murine interleukin-27-alpha, one amino acid has been exchanged, enabling the formation of a disulfide-bridge (marked in red). Image: M. Feige / TUM

Small infections can be fatal: Millions of people die each year from sepsis, an overreaction of the immune system. A new immune signaling molecule, designed by a research team from the Technical University of Munich (TUM), now provides the basis for potential new approaches in sepsis therapy.

Contact for scientific information:
Prof. Dr. Matthias J. Feige
Technical University of Munich
Laboratory for Cellular Protein Biochemistry
Lichtenbergstr. 4, 85748 Garching; Germany
Tel.: +49 89 289 13667 – E-Mail: matthias.feige@tum.de
https://www.cell.ch.tum.de
Original publication:
Stephanie I. Müller, Antonie Friedl, Isabel Aschenbrenner, Julia Esser-von Bieren, Martin Zacharias, Odile Devergne, Matthias J Feige:
A folding switch regulates interleukin 27 biogenesis and secretion of its alpha subunit as a cytokine
PNAS, 16.01.2019 – DOI: 10.1073/pnas.1816698116
Link: https://www.pnas.org/content/early/2019/01/15/1816698116
More information:

https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/35210/ Link to the press release

Evolution of signaling molecules opens door to new sepsis therapy approaches

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