23. Januar 2019, 11:15
Research results, Scientific Publications
Evolution of signaling molecules opens door to new sepsis therapy approaches
Small infections can be fatal: Millions of people die each year from sepsis, an overreaction of the immune system. A new immune signaling molecule, designed by a research team from the Technical University of Munich (TUM), now provides the basis for potential new approaches in sepsis therapy.
Contact for scientific information:
Prof. Dr. Matthias J. Feige
Technical University of Munich
Laboratory for Cellular Protein Biochemistry
Lichtenbergstr. 4, 85748 Garching; Germany
Tel.: +49 89 289 13667 – E-Mail: matthias.feige@tum.de
https://www.cell.ch.tum.de
Original publication:
Stephanie I. Müller, Antonie Friedl, Isabel Aschenbrenner, Julia Esser-von Bieren, Martin Zacharias, Odile Devergne, Matthias J Feige:
A folding switch regulates interleukin 27 biogenesis and secretion of its alpha subunit as a cytokine
PNAS, 16.01.2019 – DOI: 10.1073/pnas.1816698116
Link: https://www.pnas.org/content/early/2019/01/15/1816698116
More information: